| 摘要: |
| 布鲁氏菌病是一种严重危害人和动物健康的人畜共患病，人群感染主要来源于感染的动物及被污染的畜产品，目前疫苗免疫仍是控制动物布鲁氏菌病的主要措施。现有国际参考疫苗主要有牛种疫苗株S19和羊种疫苗株Rev.1，这些疫苗为动物群布鲁氏菌病控制提供重要保障的同时也存在关键的技术瓶颈问题，如安全性差，接种动物出现流产；血清抗体体内持续时间较长，干扰常规诊断等。随着布鲁氏菌基因组测序工作的相继完成及DNA重组技术的发展，新型布鲁氏菌病疫苗的开发成为研究的热点。亚单位疫苗本着其较高的安全性和有效性，在动物群布鲁氏菌病控制过程中具有较大的应用前景。笔者综述了布鲁氏菌病疫苗的发展史，并对布鲁氏菌病亚单位疫苗的研究进展进行概述。 |
| 关键词: 布鲁氏菌病 疫苗 亚单位疫苗 研究进展 |
| DOI：10.11841/j.issn.1007-4333.2014.03.23 |
| 投稿时间：2013-09-20 |
| 基金项目:国家“973"计划项目（2010CB530202）；北京农学院大北农青年教师科研基金（13ZK005） |
|
| History of the development of animal Brucella vaccines andthe research progress for subunit vaccine |
|
WANG Zhen1, HAN Gilsu2, WU Qing-min2
|
| (1.Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China;2.College of Veterinary Medicine, China Agricultural University, Beijing 100193, China) |
| Abstract: |
| Brucellosis is a zoonotic disease that endanger the health of human and animal.The infected animals and contaminated livestock products are the source of human brucellosis.At the present stage, vaccination is the main measure for animal brucellosis prevention and control.The available international reference vaccines are Brucella abortus strain S19 and Brucella melitensis strain Rev.1.Although both vaccines are proven to be an effective vaccine against animal brucellosis, they also have some technological bottlenecks which may cause abortion in pregnant animals and interfere with the diagnosis by standard serodiagnostic methods.Along with the completion of the genome sequencing of Brucella and the development of DNA recombination technology, the development of novel brucellosis vaccines becomes a hot spot in research.Due to their enhanced safety and efficacy in animal models, subunit vaccines for brucellosis show a great promise for their application in livestock.This review summarizes the history of brucellosis vaccine development and the research progress of brucellosis subunit vaccines. |
| Key words: Brucellosis vaccine subunit vaccine research progress |
