| 摘要: |
| 以烟草花叶病毒 (TMV) /烟草为测试体系 ,研究了天然物 PZ1抗病毒 TMV作用机理。在离体及活体条件下 ,PZ1均可抑制病毒核酸与植物核糖体结合。在活体条件下 ,PZ1抑制 TMV- RNA及 TMV蛋白质合成。实验结果表明 PZ1的主要作用靶标为 TMV- RNA |
| 关键词: 抗病毒活性物质PZ1,烟草花叶病毒(TMV),抗病毒作用机理 |
| DOI： |
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| 基金项目:国家自然科学基金资助项目! (39970 50 1) |
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| Studies on the Mechanism of Antiviral (TMV) Active Compound PZ 1 Isolated from Chinese Medicine Plant |
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| Abstract: |
| The antiviral mechanism of natural product PZ 1 was studied by TMV/tobacco system . The antiviral (TMV) active compound PZ 1 was isolated from Chinese medicine plant. PZ 1 inhibited the combination of viral RNA with plant ribosome both in vitro and in vivo . It also inhibited the synthesis of TMV RNA and TMV protein in vivo . The results assumed that the main target of PZ 1 was TMV RNA. |
| Key words: antiviral active compound PZ_1,tobacco mosaic virus(TMV),antiviral mechanism |
