| 摘要: |
| 为了解microRNAs在马医学临床诊断、预测和治疗中的应用，本研究通过整理相关文献并进行分析，概括了microRNAs在马中的研究进展。结果表明:1)在马的正常和病变组织中，microRNAs存在差异表达，可以通过靶向抑制关键调节因子，参与调控病症相关信号通路；2)在赛马运动过程中，microRNAs的表达与能量代谢相关调控因子以及血液生理生化指标呈现一定相关性，可以用于研究运动性能相关的新型分子标记物；3)在马的繁殖方面，microRNAs被发现其靶基因可参与胎盘、胚胎、睾丸和精子的生长发育，与马的生育调控机制存在一定的联系；4)基于microRNAs显著的抑制调控作用与其靶基因的表达负相关性，microRNAs可被用于治疗和诊断不同类型的马内外科疾病。随着赛马运动的广泛普及，人们对马的健康疾病日益重视，运用microRNAs在马中的诊断治疗将成为一个新的研究领域。 |
| 关键词: 马 microRNAs 应用 |
| DOI：10.11841/j.issn.1007-4333.2022.01.11 |
| 投稿时间：2020-09-21 |
| 基金项目:国家自然科学基金项目(31960657,31961143025)；国家重点研发计划项目(2017YFE0108700),内蒙古自治区自然科学基金重大项目(2017ZD06)；内蒙古自治区科技重大专项(ZD20190039),内蒙古自治区自然科学基金项目(2019MS03064),内蒙古农业大学动物科学学院标志性成果项目(BZCG202115) |
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| Research progress and application of microRNAs in horse |
|
BAI Dongyi,ZHAO Ruoyang,HAN Haige,Togtokh,Tugeqin,Manglai
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| (College of Animal Science/Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction/Equine Research Center, Scientific Observing and Experimental Station of Equine Genetics, Breeding and Reproduction of Ministry ofAgriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot 010018, China) |
| Abstract: |
| To provide an overview of microRNAs in medical clinical diagnosis, prediction, and treatment for horses in further studies, the research progress of microRNAs in horses were summarized by sorting out and analyzing the relevant literatures. The results showed that: 1)There are differential expressions of microRNAs in normal and diseased tissues of horses. microRNAs can participate in the regulation of disease-related signal pathways by targeting key regulators; 2)During horse racing, the expression of microRNAs is related to energy metabolism-related regulatory factors and blood physiology biochemical indicators, which can be used to develop new molecular markers related to sports performance; 3)In horse reproduction, microRNAs are found targeting genes involved in the growth and development of placenta, embryos, testes and sperm. There is a certain connection between microRNAs and the fertility regulation mechanism; 4)Based on the significant inhibition of microRNAs and the negative correlation with the expression of their target genes, microRNAs can be used to treat and diagnose different types of equine surgical diseases. With the popularity of horse racing, increasing attention is paid to the health of horse and their diseases, the miRNAs of horse diagnosis and disease treatment will lead to a new research field. |
| Key words: horse microRNAs application |
