| 摘要: |
| Ca2+是广泛存在的信号分子，钙信号转导对多种细胞生理生化活动有重要的调控作用，越来越多的证据表明钙信号参与卵母细胞减数分裂。钙稳态是细胞内Ca2+信号在时间和空间上的动态平衡，对卵母细胞钙稳态的研究是目前重要的研究热点之一。本文综述了钙稳态及钙离子对卵母细胞成熟和发育过程中的双线期阻滞恢复、MⅡ期阻滞恢复和细胞凋亡的作用，发现某些哺乳动物双线期及MⅡ期适当增加胞内钙离子水平可以使卵母细胞退出阻滞，而超出生理水平的胞内钙则会诱导细胞凋亡，并通过探究钙离子在卵母细胞减数分裂恢复和调控凋亡过程中的作用机制，为辅助生殖技术的进一步研究提供依据。 |
| 关键词: 卵母细胞 Ca2+ 减数分裂恢复 钙稳态 |
| DOI：10.11841/j.issn.1007-4333.2019.01.07 |
| 投稿时间：2018-04-07 |
| 基金项目:国家转基因专项（2016ZX08007-002） |
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| Role of calcium ion in the critical development periods of mammalian oocytes |
|
HOU Yunpeng, LI Xue
|
| (College of Biological Sciences/State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China) |
| Abstract: |
| Ca2+ is a ubiquitous signaling molecule. Calcium signal transduction plays an important regulatory role in a variety of physiological and biochemical activities of cells. More and more evidence shows that Calcium signal is involved in oocytes meiosis. Calcium homeostasis is the dynamic balance of intracellular Ca2+ signals in both time and space. The study of calcium homeostasis in oocytes is one of the important research hotspots. This article reviews the effects of calcium homeostasis and calcium on the meiotic resumption from diplotene arrest, meiotic resumption from MⅡ arrest and apoptosis. Studies have found that in certain mammals, oocyte exit the block from both the diplotene and MⅡ phases by appropriately increasing intracellular calcium levels, however, intracellular calcium that exceeds the physiological level will induce apoptosis. To explore the mechanism of calcium ions in meiotic resumption and apoptosis in oocytes is beneficial to the further study of assisted reproductive technology. |
| Key words: oocyte Ca2+ meiotic resumption calcium homeostatic |
