| 摘要: |
| 用遗传密码词典中61个密码作为链的状态,提出了一个氨基酸替代的马氏链模型。将20种氨基酸间首次通过时间作为突变距离与 Grantham(1974)的氨基酸间理化距离以及Dayhoff(1978)的相对替代概率做相关分析。结果表明,替代概率与理化距离的相关大大高于与突变距离间的相关,说明蛋白质进化过程中,是自然选择而非突变起着决定性作用。 |
| 关键词: 氨基酸距离 马氏链模型 蛋白质进化 |
| DOI： |
| 投稿时间：1993-03-10 |
| 基金项目: |
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| Distances among Amino Acids and Stochastic Model of Protein Evolution |
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| Abstract: |
| A Markov chain model for the evolution of protein was pressented with the 61 codons cor- responding to the states of the chain.The mean first passage time between amino acids was used as muta- tional distance(d_3)to perform correlation analysis with the physicochemical distance(d_2)of Grantham (1974)and the relative mutation probability(d_1)of Dayhoff et al.(1978).The results showed that d_1 is much more highly correlated with d_2 than with d_3,implying that selection rather than mutation must have played a... |
| Key words: distances among amino acids Markov model protein evolution |
