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球痢灵在鸡体内残留动态的研究
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摘要:
球痢灵是(D.O.T.)是一种较理想的抗球虫药。药效稳定,不易产生抗药性。并具有高效、低毒的优点。它的化学名称叫3,5—二硝基—邻—甲基苯甲酰胺(3,5—dinitro-o-toluamide)。此药早由我校完成了小试。目前由张家口地区长城化工厂进行了中试,并准备正式投产。为配合用国产球痢灵中试产品进行的动物试验,作者对其在鸡体内的残留动态进行了研究。
关键词:  二氯甲烷  标准溶液  球痢灵  抗药性  抗球虫药  张家口地区  重氮甲烷  分析结果  动物试验  无水硫酸钠  
DOI:
基金项目:
RESARCH FOR MOVEMENETS OF ZOALENE RESIDUES IN CHICKENS
Abstract:
The ground tissue was extracted with 1:1 methanol and dichlorom- ethane.The organic phase was concentrated by KD concentrator. D.O.T.must be hydralyzed by 70% sulfuric acid and extracted with dichloromethane.After that,it was concentrated and esterified by certain amount of diazomethane and then determined by gas chromato- graphy with an electron capture detector. The method will determine as low as 0.01 ppm D.O.T.in muscle tissue.This analytical method of D.O.T.was not described previously. 24 hours after ...
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