| 摘要: |
| 本文报告 SM2在育成鸡体内的药代动力学过程及其生物利用度的研究。口服 SM2(100毫克/公斤)胶囊剂后,药一时曲线呈单指数下降,符合开放式一室模型,并计算药代动力学参数 t1/2Ka,t_1/2β,tCP(they),tP,AUC,Cmax 分别为0.85±0.081小时,11.92±2.16小时,11.33±0.55小时,3.48±0.27小时,1.55±0.14毫克/毫升·小时,74.0±4.1微克/毫升。交叉试验,快速静脉推注同剂量 SM_2时。药一时曲线呈双指数曲线下降,理论值与实测值极为吻合。静注后t_(1/2B),T_(CP),V_d,AUC 分别为10.65±1.20小时,14.43±1.25小时,778±32毫升/公斤,1.97±0.16毫克/毫升·小时。口服 SM2胶囊剂的生物利用度 F(%)=77.83±2.16。 |
| 关键词: 生物利用度 指数曲线 胶囊剂 动物血药浓度 静脉推注 药代动力学参数 开放式 |
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| A STUDY ON PHARMACOKINETICS OF SULFAMETHAZINE IN CHICKENS |
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| Abstract: |
| This paper reports on the study of the dynamic relationship,in terms of time,in the process of sulfamethazine and sodium sulfameth- azine in four-and-half-month-old chicken's body,each single dosage being 100mg./kg.of body weight. 1.The concentration of unchanged sulfamethazine in plasma of the chikens administered orally with capsules was fitted to a lineal pharm- acokinetic model in which sulfamethazine itself obeyed one-compartm- ent pharmacokinetics.The average rate constant for overall elimination of s... |
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