| 摘要: |
| 球痢灵(D.O.T.)是一种防治鸡球虫病的优良药物,它的化学名称叫3,5-二硝基-邻-甲基苯甲酰胺(3,5-dinitro-o-toluamide)。在国内,此药已由我校完成小试,目前正由兰州兽医生物药品厂进行中试,并计划准备投产。球痢灵的起始合成原料是邻-甲基苯甲酸,先经硝化反应制得中间体3,5-二硝基-邻-甲基苯甲酸,再经酰氯化和氨 |
| 关键词: 原料中间体 二氯甲烷 球痢灵 气相色谱法 二硝基 重氮甲烷 甲基苯甲酸 气相色谱分析 |
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| THE GAS CHROMATOGRAPHIC DETERMINATION OF D.O.T.,3,5-DINITROO-TOLUIC ACID AND O-TOLUIC ACID |
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| Abstract: |
| D.O.T.,its starting material o-toluic acid and its synthetic inter- mediate 3,5-dinitro-o-toluic acid were analyzed satisfactorily by gas chromatographic method,when they were first converted into their more volatile methyl esters.In this method a specific mthylating agent,diazomethane,is used to ensure an improved yield of methyl esters. Diazomethane was prepared by reaction of hydrazine hydrate wi- th chloroform in the presence of potasium hydroxide and catalytical amount of tetrabutylammonium bromide asa... |
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